3 Amazing Benefits Of 3,3′-Diindolylmethane (DIM)


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3,3′-diindolylmethane (DIM) is the major bioactive indole in crucifers vegetables, generated upon ingestion and hydrolysis of glucobrassicin. R

Cruciferous vegetables contain bioactive precursor compounds known as glucosinolates

Major glucosinolates are glucobrassicin and glucoraphanin, the latter of which is a derivative of isothiocyanates, including sulforaphaneR

Indole-3-carbinol (I3C) rapidly converts to oligomers that include DIM, which is the major indole bioactive compound, accounting for an estimated 60% of the I3C end product. R


1. Reduces Inflammation

As a partial CB2 agonist, DIM may help with neuroinflammation by working on the endocannabinoid systemR

DIM can also protect against inflammation by acting on GPR84. R

DIM also has potent COX-2 inhibition properties. R

2. Combats Cancer

DIM is potent at fighting cancer. R

For example, DIM inhibited the growth of mammary gland cell cancer, (via modulation of estrogen receptor α and AhR). R

3. Promotes Detoxification And Antioxidant Production

Through the activation of Aryl Hydrocarbon Receptors (AhR) and Nrf2 signaling pathways, DIM effectively increases detoxification and reduces inflammatory signaling

  • DIM can modulate AhR, which promotes transcription of genes that stimulate the expression of detoxification enzymes, including the phase I cytochrome P450 (CYP) family. R
  • It can also induce the transcription factor NRF2, which has strong anti-oxidant and detoxification properties. R

My Experience With DIM

I use liposomal DIM on an empty stomach.

In a smoothie, I’ll use DIM as a powder

Where To Buy DIM

If you supplement with I3C, either take it on an empty stomach or with HCL, as the conversion of I3C to DIM is pH dependent. R

Natural Sources

Boiling increases the natural content of DIM (up to 6x). R

Brassicaceae family (cruciferous vegetables): R

  • Bok Choy
  • Broccoli
  • Brussel Sprouts
  • Cauliflower
  • Garden Cress
  • Horseradish
  • Kale
  • Kohlrabi
  • Mustard Greens
  • Red Cabbage
  • Savoy Cabbage
  • Turnip
  • Watercress

DIM Synergies

DIM goes well with Beta-Caryophyllene. R

Mechanism Of Action



  • The conversion of I3C into DIM is ~2:1. R