Natural Cyclooxygenase 2 (COX-2) Inhibitors (with Genetics and Pathways)


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COX Basics

Cyclooxygenase (COX), officially known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme that is responsible for formation of prostanoids, including thromboxane and prostaglandins such as prostacyclin.

Inhibiting COX has been used by many pharmaceuticals to reduce pain and inflammation.

For example, Nonsteroidal anti-inflammatory drugs (NSAIDs), such as aspirin and ibuprofen, exert their effects through inhibition of COX. R

COX2 Inhibitors





  • Activate AMPK R
  • Activate Endocannibinoids (take CBDTHC works, but can cause memory impairment) R R R R
  • Activate PPARgamma R
  • Activate NRF2 R
  • Increasing BDNF R
  • Inhibit FAAH R
  • Inhibit GSK-3 R
  • Inhibit HO-1 R
  • Inhibit TRPV1 R





rs20417 (I’m CC)

  • C Allele 
    • 30% higher risk of diabetes (Pima Indian population) R
    • Lower risk of end-stage Osteoarthritis R
    • Higher risk of stroke (African American population) R
    • Lower risk of Myocardial Infarction and stroke (Italian population) R
  • G Alleles
    • Greater risk of end-stage Osteoarthritis R
    • Higher benefit from NSAIDs for disease prevention R

rs5275 (I’m AG)

  • AA Allele
    • may do better with NSAIDs R
    • higher levels of COX-2 R