Glyphosate & Roundup Inhibit Vitamin D and Cause Nutritional Deficiencies

Glyphosate Creates A Leaky Gut And Dysbiosis

Since the late 1970s, the use of glyphosate-based herbicides (GBHs) has increased approximately 100-fold. R

Glyphosate is the active ingredient in Roundup®. R

In this post, we will discuss glyphosate’s toxic effects (even at extremely low doses). R




  1. Basics
  2. How Glyphosate Affects The Body
  3. Levels And Testing
  4. What You Can Do To Protect Your Body
  5. Mechanism Of Action
  6. More Research


Roundup is sprayed on almost all non organic crops. R

It gets into the water supply from runoff and rain and is able to get into organic foods, as well as meats and sea life. R R

In the past 20 years, the use of glyphosate has increased 6504% (from 1991 to 2010). R

Its found in 93% of Americans’ urine. R

Thanks Monsanto! /s

Since glyphosate (like atrazine) acts as an herbicide, antibiotic, pesticide, and anti-parasitic, it can kill the plants that it is sprayed on. R 

This has has led to the need to create genetically modified (GMO) roundup-ready plants, that do not die from glyphosate use. R

Weeds are also starting to gain resistance to roundup as well). R 

The most common roundup ready crops include:

  • Alfalfa R
  • Barley R
  • Canola (Rapeseed) R
  • Corn (Maize) R
  • Cotton R
  • Floriculture Crops R
  • Sorghum R
  • Soy R
  • Sugar R
  • Wheat R

It is illegal in Sri Lanka, The Netherlands, Argentina and Malta, but not the US or the complete EU. R 

It can cause gastrointestinal disorders, obesity, diabetes, heart disease, depression, autism, infertility, cancer and Alzheimer’s disease. R

So if glyphosate is so toxic at low doses, why is it legal (this post is unrelated to politics)? R

Well, this is because the acute effects from glyphosate (ie dysbiosis) are different than the effects of glyphosate from chronic exposure (ie Alzheimer’s Disease). 

How Glyphosate Affects The Body

1. Damages Mitochondrial Function

Glyphosate downregulates and inhibits mitochondria’s ability to produce energy (ATP). R R

It causes cells and mitochondria to self destruct (apoptosis) and die. R R

It even synergizes with the other ingredients in roundup to make it even more toxic than glyphosate alone. R

2. Depletes The Body Of Nutrients



Glyphosate kills plants by interfering with the shikimate pathway, which is necessary to make metabolites such as hormones, nutrients and amino acids. R R

Although humans do not have the shikimate pathway, the bacteria that live in and on us do, and they are severely impacted by glyphosate’s antimicrobial properties. R

We depend upon this pathway for our gut bacteria to provide us with:

  • CoQ10 R
  • Dopamine R
  • Epinephrine (Norepinephrine) R
  • Folate R
  • GABA R
  • Glycine R R
  • Melanin R
  • Melatonin R
  • Methionine (and selenomethionine) R
  • Phenylalanine R
  • Serine R
  • Serotonin (and sulfate transfer enzymes) R
  • Thyroid Hormones R
  • Tryptophan R
  • Tyrosine R
  • Vitamin E R
  • Vitamin K R  

The decrease in these nutrients lead to depression, decreased ability to handle UV radiation from the sun, impaired sleep regulation, and decreased communication between the brain and gut. R

Glyphosate shifts minerals around in the body and puts them in the wrong places (such as manganese, cobalt, molybdenum, copper, iron, sulfur, and selenium), causing deficiency and toxicity at the same time. R R

Glyphosate also decreases the amount of calcium, magnesium, iron, and manganese (Mn) in plants. R R

On top of that, GMO/roundup ready food usually is depleted of Mn. R

Mn is essential for preventing mitochondrial damage, Alzheimer’s disease, Parkinson’s disease, prions disease, sperm damage, autism spectrum disorders, anxiety, and depression. R

Glyphosate oxidizes Mn in the body making it dangerous and toxic. R

3. Disrupts Hormones

Glyphosate is an estrogenic substance, which means it works on and disrupts estrogen receptors. R

It makes both men and women infertile, by damaging sperm and eggs. R R 

Glyphosate suppresses aromatase, which is necessary to convert testosterone to estrogen, thus creating an imbalance in the regulation of sex hormones. R 

This even happens at extremely low doses (800x below the legal limits). R

It also inhibits the ability to produce steroid hormones. R

Glyphosate also depletes the body of methionine and selenium, which are necessary to make thyroid hormones. R

Also, glyphosate inhibits the body’s ability to create active vitamin D, which its receptors are widely found in the brain and liver, thus glyphosate blocks the ability to make vitamin D from the sunR

Active vitamin D has a myriad of benefits such as preventing inflammatory, autoimmune, cardiovascular, neuromuscular, and neurodegenerative diseases, as well as cancer. R

4. Damages The Brain

Glyphosate is neurotoxic, which means it damages neurons. R 

Glyphosate also turns off the brains ability to heal itself after head trauma (such as a stroke or concussion). R

This creates a constant immune/inflammatory response in the brain. R

Glyphosate also increases ammonia in the gut, which is toxic to the liver and brain (causing impaired memory, shortened attention span, sleep–wake cycle disruption, brain edema, intracranial hypertension, seizures, ataxia, coma, and multiple sclerosis). R

Glyphosate has been found to be in vaccines and can make vaccines more toxic to the body. R 

This is because glyphosate works synergistically with the aluminum, mercury, and glutamate in vaccines. 

It can also take these heavy metals and transport them through the gut and across the blood brain barrier. R R

For example, aluminum combined with glyphosate can induce immunoexcitotoxicity (hyper-activation of the immune system) in the body and brain. R R

Glyphosate increases glutamate in the hippocampus, causing memory loss and oxidative stress on the brain. R

It also decreases GABA and dopamine, contributing to the development of Parkinson’s Disease. R R

Glyphosate also increases Lewy bodies in the brain. R

Glyphosate has also been linked to the development of Amyotrophic Lateral Sclerosis (ALS). R

5. Causes Liver and Kidney Disease



Glyphosate overloads the liver and kidneys. R

Glyphosate inhibits the ability for humans to detox foreign chemicals (such as pesticides or drugs like tylenol). R

It also disrupts the metabolism of cholesterol. R

Glyphosate also increases the chance of developing cholestasis (impaired flow of bile from the liver), which inhibits the excretion of toxins. R

This increases the chance of forming gallstones and developing pathogenic bacteria in the liver. R

It also increases the chances of developing non-alcoholic fatty liver disease (NAFLD), cirrhosis (scarring) and fibrosis of the liver. R R

Glyphosate exposure (even exposure at an early age) makes you more susceptible to developing metabolic syndrome and Type 2 Diabetes. R R R

Glyphosate also depletes glutathione (GSH) and glutathione S transferase (GST) which are critical enzymes for liver detoxification of arsenicR

As a consequence, excess arsenic in the kidneys causes acute kidney failure. R

Also glyphosate increases oxalate release from plants, increasing the chance of developing kidney stones. R

6. Creates Dysbiosis and Leaky Gut

Glyphosate directly causes dysbiosis (imbalance of good and bad bacteria). R

Glyphosate kills most of the beneficial strains of bacteria in our gut:

  • Bacillus badius R
  • Bifidobacterium adolescentis R
  • Enterococcus faecalis R
  • Lactobacillus spp. R

Many pathogenic strains of bacteria are resistant to glyphosate:

  • Clostridium botulinum R
  • Clostridium perfringens R
  • Salmonella Entritidis R
  • Salmonella Gallinarum R
  • Salmonella Typhimurium R

Glyphosate blocks Enterocccus’s ability to inhibit clostridium infections, which is a part of the pathology of many inflammatory bowel diseases, such as Crohn’s Disease. R R

It inhibits lactobacillus’s ability to create lactic acid and break down phytate. R R

It also increases the growth of alfatoxins. R

Certain Pseudomonas species in our gut will take glyphosate and metabolize it into formaldehyde, which is toxic to the brain. R

Glyphosate can also make the microbiome resistant to antibiotics. R

It also reduces bacteria’s ability to produce short chain fatty acids (SFCAs) such as butyrate. R R

Glyphosate also breaks down tight junctions in the gut. R

Tight junctions are necessary for keeping the cell wall in the gut together tightly so no foreign materials get into the blood. R

Disruptions of tight junctions are also known as leaky gut or intestinal permeability. R

This increases the chance of developing celiac disease, gluten sensitivity, and food intolerances. R

So does the increased spraying of glyphosate on wheat over the years.

This is because the microbiome programs the immune system as to what is a friend or foe. R

This same mechanism (glyphosate from air exposure) increases the chances of developing lung diseases and asthma. R

Glyphosate exposure also directly stimulates a TH2 immune response. R

7. Causes Cancer

There have been many studies linking glyphosate to cancer. R R

Glyphosate has been linked to causing:

  • Breast Cancer R
  • Hodgkin lymphoma R
  • Leukemia R
  • Melanoma R
  • Multiple Myeloma R
  • Non-Hodgkin Lymphoma R

8. Developmental Defects



There is an increased incidence of severe birth defects in Argentina and Paraguay from glyphosate use in:

  • Poultry R
  • Young pigs R

Glyphosate also impairs mechanisms that help produce normal facial features and bone structure. R

In pregnant and lactating rats given sub-lethal doses of glyphosate, their offspring had decreased loco-motor activity and appeared anxiety levels. R

Levels And Testing

Obviously, glyphosate is not required to live and there should be no presence of it in blood or urine.

You can test your levels here.

What You Can Do To Protect Your Body




This list applies to pets as well. R

All of these products have been shown to contain glyphosate:

  • Bad Air Quality (and get a HEPA FilterR
  • Feminine Hygiene Products (tampons, pads, wipes, douches, deodorants, itch creams, etc) R R
  • *GMO Food (baby foods, ALL grain-based and soy-based products, meats, oils, fruits, vegetables, sugars/corn syrups/honeys) R R R R
  • Ground Water (and wells) R
  • Hospital Feeding Tubes R
  • Some Wildlands R
  • Tap Water (and get a Berkey Filter and a Shower Filter) R R

Protect Against Roundup

Hyperimmune Egg + Restore4Life + activating NRF2 is probably the best way to protecting against glyphosate. 

Also, in animal models, eating a diet high in aromatic proteins (such as tyrosine, tryptophan, and phenylalanine) may help compensate for nutrient loss and the anitmicrobial effect of glyphosate. R

If you grow your own food, using humic acid should help neutralize any antimicrobial effect glyphosate has on beneficial gut bacteria. R


Mechanism Of Action


Roundup contains surfactants such as POEA (discussed below), which are actually more toxic than glyphosate. R R


  • Glyphosate changes the way how bacteria produce necessary vitamins that our body needs.
  • This creates a downward cascade for deficiencies in the body that are the building blocks necessary for our brain to make neurotransmitters, reduce inflammation, create antioxidants, and synthesize certain hormones.
  • Glyphosate also opens up the gut similarly to how gluten works on the cell lining, which allows foreign proteins to come in an activate the immune system.


  • Glyphosate (N-phosphonomethyl glycine) is metabolized into aminomethylphosphonic acid (AMPA) and methylphosphonic acid and its impurities: N-(phosphonomethyl)iminodiacetic acid (PMIDA), N-methylglyphosate, hydroxymethylphosphonic acid and bis-(phosphonomethyl)amine in the body. R R
  • Glyphosate inhibits the activity of the enzyme synthase 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) by competitive inhibition, which prevents the production of chorismate that is a precursor for aromatic amino acids using in the synthesis of a number of pigments, flavonoids and anthocyanins. R
  • Glyphosate binds to the CP4 EPSP synthase in a condensed, noninhibitory conformation. R
  • Glyphosate inhibits the transport of free sulfate in the blood, brain and CSF – disrupting the ability to convert amino acids into usable neurotransmitters and keep homeostasis of DHEA and Vitamin D3. R
  • Glyphosate inhibits glycine synthesis. R
  • Since glyphosate reduces and mimics the structure of glycine, it can activate NMDA and enhance the development of Parkinson’s disease. R
  • In mitochondria glyphosate increases pyruvate and fermentation (lactate). R
  • Glyphosate inhibits cytochrome P450 enzymes, GSH and GPX. R R
  • Roundup inhibits steroidogenesis by disrupting steroidogenic acute regulatory (StAR) protein expression. R
  • StAR protein mediates the rate-limiting and acutely regulated step in steroidogenesis, the transfer of cholesterol from the outer to the inner mitochondrial membrane where the cytochrome P450 side chain cleavage (P450scc) enzyme initiates the synthesis of all steroid hormones. R
  • Glyphosate enhances the oxidation of Mn from a 2+ oxidation state to 3+, thus making manganese in the body toxic. R
  • Exposure to excess Mn3+ leads to a decrease in the bioavailability of dopamine, serotonin, and noradrenaline in the striatum. R
  • Mn3+ also enhances glyphosate degradation to AMPA, causing more inflammation. R
  • Sat-1, glyoxylate, and oxalate disrupt sulfate homeostasis in the liver. R
  • Mn deficiency due to glyphosate’s chelation of the metal can lead to impaired arginase function, impairing nitric oxide. R
  • Glyphosate kills dopaminergic cells in the substantia nigra. R
  • Glyphosate is an acetylcholinesterase inhibitor. R
  • Ammonia also decreases the neurotransmitter glutamate in certain parts of the brain, but increases glutamate in the hippocampus via induction of Ca2+ influx through L-VDCC and NMDA receptor activation. R
  • Glyphosate increases the production of zonulin, which enhances the opening of tight junctions. R
  • It is 10x as more powerful then gluten – at dietary levels does the same as gluten to tight junction electrical charge (30%).
  • Exposure to glyphosate-rich air samples as well as glyphosate alone to the lungs increased: eosinophil and neutrophil counts, mast cell degranulation, and production of IFN-gamma, IL-10, IL-33, TSLP, IL-13, and IL-5. R
  • The acute oral lethal dose (LD50) in rats is > 4320 mg/kg, dermal LD50 is > 2 g/kg and inhalation lethal concentration 50 is > 4.43 mg/l. R
  • Glyphosate may cause birth defects because of its ability to impair retinoic acid signaling. R
  • Glyphosate passes through the gut barrier, blood brain barrier, and mucousal barrier in the nose. R

More Research

  • In the presence or absence of glyphosate, corn and soybean rhizospheres were dominated by members of the phyla Proteobacteria, Acidobacteria, and Actinobacteria. R
  • Tetrachlorvinphos, parathion, malathion, and diazinon (other pesticides) may also have carcinogenic properties. R
  • Glyphosate 1992-2012 V
  • Salicylic acid may protect tomatoes against glyphosate-induced stress. R