Noopept is a performance-enhancing peptide for the brain that enhances the sound and flow of music, concentration, and motivation. It isn’t a recreational drug and it is 100% legal to buy and use.
- My Experience with Noopept
- Side Effects
- Biosynthesis for Noopept
- Mechanism Of Action
- Where to Buy Noopept
- More Studies
Noopept is a smart drug that is usually prescribed in Russia. R
It has been found to be 1000 times more potent than piracetam. R
Noopept isn’t active until metabolized into cycloprolyglycine. R
1. Helps Enhance Memory
Acute administration of Noopept 24 hours after a learning process is still associated with a degree of memory enhancement in rats. R
2. May Prevent and Repair Cerebral Trauma
Noopept at 10mg twice daily appeared to be effective in aiding in the recovery of brain damage from vascular damage. Noopept was also effective against physical trauma. R
Noopept may be associated with protection against stroke, by opening potassium channels, having a modulatory effect. R
α-synuclein is a major constituent of Lewy bodies (protein clumps that are the pathological hallmark of Parkinson’s disease). Noopept at a 1:1 ratio or ten-fold greater seemed to stop α-synuclein-induced cytotoxicity. R R
3. Reduces Immunosuppression
Chronic dosing of Noopept for 7 days showed enhanced T-cell proliferation. R
4. Relieves Anxiety
Along with Piracetam, Noopept was taking 56 days by 53 persons with cognitive ailments (either vascular cerebral damage or post-traumatic damage). The vascular cerebral damage group showed better mood, sleep, and wakefulness while both groups had reduced fatigue, anxiety, irritability, apathy, and affective lability. R
5. Has Antidepressant Effects
When 20mg of Noopept was taken for 56 days, there were less depressive symptoms associated with test subjects. R
My Experience with Noopept
I took around ~10mg (maybe less) of noopept sublingually (held under the tongue for 5 min and then swallowing the rest with water) in the morning. It tastes awful. I had to drink a green juice after to avoid nausea.
I felt clean energy and reduced anxiety. This lasted most of the day, but by around the evening, I felt dizzy, tired and achy. The positive effects lasted the next day too.
After a few weeks of dosing, I started to feel “emotional dulling”. The best way I can describe this is that I was very logical, but had very little emotions (highs or lows).
Update: A few weeks later after using it, the emotional dulling is still present. I would call myself a lot more logical than I used to be. They may be a good peptide for bipolar patients since I have no mood swings. Unfortunately, I have a lot less “highs”.
Ampakines can cause emotional blunting, sort of like Autism-like symptoms. R
Be wary that the majority of studies with Noopept have been in rodents or animals. Hopefully more human studies will come out in the future.
Here is a list of common side effects:
- Appetite changes
- Brain fog
- Cognitive impairment
- Mood swings
- Memory impairment
- Motivational deficits
- Muscle aches
- Physical Weakness
- Rapid thinking
- Sleep disturbances
- Temperature changes
- Tingling sensations
- Visual changes
- Weight changes
If you have a side effect like the ones listed above, take a lower dose! Remember, the minimum effective dose is what you should go for.
Noopept has an “M” Shaped response curve, meaning that you’ll feel the strongest effects at a dose of about 10-15mg and then again at ~150mg. Any dose in between the two isn’t going to work out quite as planned.
Most people take it sublingually. I’ve heard of it being used in alcohol to enhance alcohol’s effects. R
I never tried that as I don’t drink.
Biosynthesis for Noopept
The best method of delivery has been shown to be oral ingestion. R
Noopept can easily cross the blood-brain barrier. R
Mechanism Of Action
Where to Buy Noopept
- In mice with a cholinergic deficit, it did not improve long-term memory. This may suggest that supplementing choline will enhance its hippocampal formation and function. R R R R
- Noopept does not cause tolerance. Chronic administration even makes the effects more noticeable. R
- It may be wise to cycle Noopept as BDNF (in rats) down-regulates neurotrophin responsiveness, TrkB protein, and TrkB protein and mRNA levels. R